Effects of epidermal growth factor/urogastrone and associated pancreatic hormones on mitotic cycle phases and proliferation kinetics of neonatal rat hepatocytes in primary culture.


Low doses (10(-14)--10(-11) M) of epidermal growth factor (EGF)/urogastrone and/or equimolar mixtures of glucagon and insulin administered to 4-day-old primary neonatal rat liver cultures stimulated both DNA synthesis and proliferation of hepatocytes within 24 h. The precise roles played in this process by EGF and the two pancreatic hormones were… (More)


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