Effects of epidermal growth factor, transforming growth factor alpha and androstenedione on follicular growth and aromatization in culture.

@article{Almahbobi1995EffectsOE,
  title={Effects of epidermal growth factor, transforming growth factor alpha and androstenedione on follicular growth and aromatization in culture.},
  author={Ghanim Almahbobi and A Nagodavithane and Alan O. Trounson},
  journal={Human reproduction},
  year={1995},
  volume={10 10},
  pages={2767-72}
}
The effects of epidermal growth factor (EGF), transforming growth factor alpha (TGF alpha) and androstenedione on follicular growth and oestradiol production were studied in cultured mouse preantral follicles. Cultured follicles in the control group showed growth and steroidogenic capacities up to the antral follicle stage at day 4 of culture. However, many of these follicles failed to resume their growth during the culture. Increasing concentrations of EGF and TGF alpha decreased the number of… CONTINUE READING