Effects of epicatechin on rat islets of Langerhans.

@article{Hii1984EffectsOE,
  title={Effects of epicatechin on rat islets of Langerhans.},
  author={Charles S. T. Hii and Simon James Howell},
  journal={Diabetes},
  year={1984},
  volume={33 3},
  pages={291-6}
}
Plants containing epicatechin (a flavonoid) have been used to treat diabetes mellitus in Indian medicine. The present study reports effects of this compound on isolated islets of Langerhans. The flavonoid (1 mM) was found to increase insulin secretion from isolated rat islets of Langerhans in the presence of either 2 or 20 mM glucose, in static incubations, or in perifusion. The increase in insulin secretion mediated by epicatechin was both ATP- and temperature-dependent. Ultrastructural… CONTINUE READING
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