Effects of enzyme inhibitors and insulin concentration on transepithelial transport of insulin in rats.

@article{Bai1996EffectsOE,
  title={Effects of enzyme inhibitors and insulin concentration on transepithelial transport of insulin in rats.},
  author={Jane P. F. Bai and Liuquan ' Lucy ' Chang},
  journal={The Journal of pharmacy and pharmacology},
  year={1996},
  volume={48 10},
  pages={1078-82}
}
The objective of this study was to determine whether transepithelial transport of insulin can be improved by enzyme inhibitors and whether insulin concentration affects its ileal absorption. Ussing chambers and radioimmunoassay were used to study insulin transport across the rat ileum, and circular dichroic spectra were used to determine whether insulin aggregated at high concentrations. Inhibitors that inhibit insulin-degrading enzyme, including N-ethylmaleimide, 1,10-phenanthroline and p… CONTINUE READING