Effects of environmental enrichment on gene expression in the brain.

  title={Effects of environmental enrichment on gene expression in the brain.},
  author={Claire Rampon and Cecilia H Jiang and H Dong and Y. P. Tang and David J Lockhart and Peter G. Schultz and Joe Z. Tsien and Yiping Hu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 23},
An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

2 Figures & Tables