Effects of enrofloxacin on porcine phagocytic function.

  title={Effects of enrofloxacin on porcine phagocytic function.},
  author={Eric J Schoevers and Leo A M G van Leengoed and Jos H. M. Verheijden and Theo A. Niewold},
  journal={Antimicrobial agents and chemotherapy},
  volume={43 9},
The interaction between enrofloxacin and porcine phagocytes was studied with clinically relevant concentrations of enrofloxacin. Enrofloxacin accumulated in phagocytes, with cellular concentration/extracellular concentration ratios of 9 for polymorphonuclear leukocytes (PMNs) and 5 for alveolar macrophages (AMs). Cells with accumulated enrofloxacin brought into enrofloxacin-free medium released approximately 80% (AMs) to 90% (PMNs) of their enrofloxacin within the first 10 min, after which no… CONTINUE READING