Effects of enprostil on platelets, endothelial cells, and other cell types, and second messenger systems by which these effects are mediated.

@article{Allison1986EffectsOE,
  title={Effects of enprostil on platelets, endothelial cells, and other cell types, and second messenger systems by which these effects are mediated.},
  author={Anthony C. Allison and Witold J. Kowalski and Berta Strulovici},
  journal={The American journal of medicine},
  year={1986},
  volume={81 2A},
  pages={
          34-9
        }
}
In human blood platelets, thromboxane A2, prostaglandin E2, and its analogue enprostil activate protein kinase C and promote the second phase of aggregation, whereas prostacyclin and prostaglandin E1 activate adenylate cyclase and inhibit aggregation. In each case, a characteristic group of proteins is phosphorylated following agonist binding. These observations may be related to the inhibitory effect of enprostil on the activation of adenylate cyclase in gastric parietal cells, which follows… Expand
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