Effects of enoxacin, ofloxacin and norfloxacin on theophylline disposition in humans

@article{Sano2004EffectsOE,
  title={Effects of enoxacin, ofloxacin and norfloxacin on theophylline disposition in humans},
  author={Masatoshi Sano and Kazuo Kawakatsu and C. Ohkita and Ikuyoshi Yamamoto and Masami Takeyama and Hajime Yamashina and Mitsuyoshi Goto},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={35},
  pages={161-165}
}
SummaryThe effect of three new fluoroquinolones on theophylline kinetics and the urinary excretion of metabolites was studied in 5 healthy subjects (3 male, 2 female).All subjects received serial, single i.v. infusions of theophylline (aminophylline, 250 mg) over 60 min after 200 mg doses of a quinolone (enoxacin, ofloxacin, norfloxacin) every 8 h for 3 consecutive days, the quinolone being administered up to the day following theophylline administration.Pretreatment with ofloxacin and… 
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The results indicate that fluconazole is a minor inhibitor of theophylline disposition compared with enoxacin, and they suggest that the inhibitory action of fluconAZole is selective for certain cytochrome P-450 isozymes, but not for the cyto chrome P-4501A involved in theophyLLine metabolism.
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The mechanism of the theophylline-quinotone interaction in the kidney is elucidated by examining the effect of co-administration of enoxacin, ofloxac in and norfloxacIn with theophylla on the renal excretion of theophyLLine.
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EFFECT OF THEADDITION OF CIPROFLOXACIN ON THEOPHYLLINE PHARMACOKINETICS IN SUBJECTS INHIBITED BYCIMETIDINE
OBJECTIVE: Although the effect of individual enzyme inhibitors on hepatic microsomal enzyme activity has been studied extensively, little data exist on the effects of combinations of inhibiting
THE INHIBITORY EFFECTS OF THE FLUOROQUINOLONE ANTIMICROBIALS NORFLOXACIN AND ENROFLOXACIN ON HEPATIC MICROSOMAL CYTOCHROME P-450 MONOOXYGENASES IN BROILER CHICKENS
The fluoroquinolone antimicrobials norfloxacin and enrofloxacin were found to inhibit hepatic microsomal cytochrome P-450 monooxygenases in the livers of broiler chickens using dosages as given in
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