Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis.

@article{Carbone2013EffectsOE,
  title={Effects of energy deficit, dietary protein, and feeding on intracellular regulators of skeletal muscle proteolysis.},
  author={John William Carbone and Lee M. Margolis and James P. McClung and J. James Cao and Nancy Elizabeth Murphy and Edward R Sauter and Gerald F. Combs and Andrew J. Young and Stefan Michael Pasiakos},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 12},
  pages={
          5104-11
        }
}
This study was undertaken to characterize the ubiquitin proteasome system (UPS) response to varied dietary protein intake, energy deficit (ED), and consumption of a mixed meal. A randomized, controlled trial of 39 adults consuming protein at 0.8 (recommended dietary allowance [RDA]), 1.6 (2×-RDA), or 2.4 (3×-RDA) g · kg(-1) · d(-1) for 31 d. A 10-d weight maintenance (WM) period was followed by 21 d of 40% ED. Ubiquitin (Ub)-mediated proteolysis and associated gene expression were assessed in… CONTINUE READING
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