Effects of endotoxin on iron uptake by the hepatocyte.

  title={Effects of endotoxin on iron uptake by the hepatocyte.},
  author={Barry J. Potter and Barbara L Blades and Thomas A McHugh and Ross Nunes and Oscar Beloqui and P A Slott and Jacob H. Rand},
  journal={The American journal of physiology},
  volume={257 4 Pt 1},
Administration of endotoxins is often followed within 12-24 h by marked hypoferremia. Because the hepatocyte is the major site of both iron storage and transferrin synthesis, we have investigated the effects of an Escherichia coli endotoxin (lipopolysaccharide, LPS) on these parameters on isolated hepatocytes from normal Wistar rats (ND), rats previously treated intraperitoneally with 2.5 mg/kg (LD) or 25 mg/kg (HD) LPS, and control rats injected intraperitoneally with sterile saline (CD). No… CONTINUE READING

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