Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1

@inproceedings{Sordillo2011EffectsOE,
  title={Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1},
  author={Joanne E Sordillo and Sunita Sharma and Audrey H. Poon and Jessica Lasky-Su and Kathleen D Belanger and Donald K. Milton and Michael B. Bracken and Elizabeth W. Triche and Brian P. Leaderer and Diane R. Gold and Augusto A Litonjua},
  booktitle={BMC Medical Genetics},
  year={2011}
}
BackgroundPolymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence asthma risk in children.MethodsIn a previous analysis of 372 children from the Boston Home Allergens and the Connecticut Childhood Asthma studies, 7 SNPs in 6 genes (CARD15, TGFB1, LY96, ACAA1, DEFB1 and IFNG) involved in innate immune pathways were associated with asthma… CONTINUE READING

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