Effects of endotoxin, interleukin-1 beta and prostaglandin injections on fever response in broilers.

@article{Macari1993EffectsOE,
  title={Effects of endotoxin, interleukin-1 beta and prostaglandin injections on fever response in broilers.},
  author={Marcos Macari and Renata L de Ara{\'u}jo Furlan and F P Gregorut and E R Secato and Juliano Rodrigo Guerreiro},
  journal={British poultry science},
  year={1993},
  volume={34 5},
  pages={1035-42}
}
1. The effect of endotoxin, interleukin-1 beta and prostaglandin on fever response was studied in 80 broilers (Hubbard strain). Endotoxin (E. coli, LPS) was injected i.v. (1.5 micrograms/kg) and icv (1.5 micrograms/bird); interleukin-1 (human recombinant IL-1 beta, 80 pg/bird) and prostaglandin E2 (5 micrograms/bird) were injected icv. Indomethacin (10 mg/kg, i.v.) pretreatment was also used before i.v. endotoxin injection. 2. The results showed that indomethacin was able to block the fever… CONTINUE READING

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