Effects of endothelins (ET-1, ET-2 and ET-3) in the rabbit eye; role of prostaglandins.

@article{Granstam1991EffectsOE,
  title={Effects of endothelins (ET-1, ET-2 and ET-3) in the rabbit eye; role of prostaglandins.},
  author={Elisabet Granstam and Lanlan Wang and Anders Bill},
  journal={European journal of pharmacology},
  year={1991},
  volume={194 2-3},
  pages={217-23}
}
The effects of intracameral injection of three endothelin isopeptides (ET-1, ET-2 and ET-3) were studied in the rabbit eye. All three peptides at pmol doses caused a dose-dependent rise in intraocular pressure (IOP) and an increase in protein concentration in the aqueous humor, indicating breakdown of the blood-aqueous barrier. Mean arterial blood pressure was not affected. ET-1 was more effective to increase IOP than were ET-2 and ET-3 whose effects seemed to be equal. ET-1 also caused… CONTINUE READING

Similar Papers

Loading similar papers…