Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat.

@article{Kelly2000EffectsOE,
  title={Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat.},
  author={Darren J. Kelly and Sandford L. Skinner and Richard E Gilbert and Alison J. Cox and Mark Emmanuel Cooper and Jennifer Louise Wilkinson-Berka},
  journal={Kidney international},
  year={2000},
  volume={57 5},
  pages={1882-94}
}
BACKGROUND Endothelin (ET) and angiotensin II (Ang II) are vasoactive/trophic peptides that may contribute to the progression of diabetic nephropathy. The transgenic (mRen-2)27 rat exhibits overexpression of Ang II at sites of normal physiological expression. Unlike other rat strains, the streptozotocin-induced diabetic Ren-2 rat develops progressive renal pathology associated with a declining glomerular filtration rate (GFR) and provides a convenient model to evaluate the role of these… CONTINUE READING