Effects of endothelin a receptor blockade on endothelial function in patients with chronic heart failure.

@article{Berger2001EffectsOE,
  title={Effects of endothelin a receptor blockade on endothelial function in patients with chronic heart failure.},
  author={Rolando Berger and Brigitte Stanek and Martin Huelsmann and Bettina Frey and Sandra Heher and Richard Pacher and Thomas Neunteufl},
  journal={Circulation},
  year={2001},
  volume={103 7},
  pages={
          981-6
        }
}
BACKGROUND Chronic heart failure (CHF) is associated with impaired endothelium-dependent vasodilation and increased basal vascular tone due, in part, to elevated endothelin-1 plasma levels. In the present study, we investigated whether a reduction of vascular tone using an endothelin A receptor blocker attenuates the impairment of endothelium-dependent, flow-mediated vasodilation (FMD). METHODS AND RESULTS Twenty-one patients with CHF randomly received either the endothelin A receptor blocker… CONTINUE READING

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