Effects of endothelial cells on human mesenchymal stem cell activity in a three-dimensional in vitro model.

@article{Saleh2011EffectsOE,
  title={Effects of endothelial cells on human mesenchymal stem cell activity in a three-dimensional in vitro model.},
  author={Fatima A Saleh and Muna Whyte and Paul Genever},
  journal={European cells & materials},
  year={2011},
  volume={22},
  pages={242-57; discussion 257}
}
An increasing body of data suggest that mesenchymal stem cells (MSCs) reside in a perivascular niche. To more closely mimic this in vivo microenvironment and for better understanding of its complexity, and the factors that regulate the MSC activity, human umbilical vein endothelial cells (HUVECs) were co-cultured with human bone marrow MSCs--using a novel three-dimensional (3D) spheroid co-culture system. Using confocal microscopy of fluorescently labelled cells, we observed HUVECs and MSCs to… CONTINUE READING

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