Effects of encainide and its metabolites on energy requirements for defibrillation.

@article{Fain1986EffectsOE,
  title={Effects of encainide and its metabolites on energy requirements for defibrillation.},
  author={Eric S Fain and P. Dorian and J M Davy and R E Kates and Roger A Winkle},
  journal={Circulation},
  year={1986},
  volume={73 6},
  pages={1334-41}
}
Encainide, a class IC antiarrhythmic agent, has been associated with proarrhythmic responses of ventricular tachycardia and fibrillation requiring defibrillation in patients. We examined the short-term effects of intravenous encainide and its two major metabolites, O-demethyl-encainide (ODE) and 3-methoxy-ODE (MODE), on the energy requirements for successful defibrillation in 25 pentobarbital-anesthetized, open-chest dogs. Truncated exponential (60% tilt) defibrillation shocks were administered… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS