Effects of elevating [Na]i on membrane currents of canine ventricular myocytes: role of intracellular Ca ions.

Abstract

OBJECTIVES Our first objective was to study how elevating [Na]i can modify the background membrane conductance in canine ventricular myocytes (CVM). In particular, we wanted to find evidence for a Nai-activated K current (IK,Na) in these cells. The second objective was to compare the effects of elevating [Na]i on membrane currents without and with… (More)

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