Effects of elevated intraocular pressure on outflow facility and TIGR/MYOC expression in perfused human anterior segments.


PURPOSE To investigate the effects of high intraocular pressure (h-IOP) on TIGR/MYOC expression, extracellular matrix (ECM) deposition, and outflow facility (C) in perfused human anterior segment cultures. METHODS Anterior segments of 31 pairs of normal human eyes from postmortem donors were perfused at constant flow (3 microl/min). After reaching stable… (More)


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