Effects of electrostatic interactions on ligand dissociation kinetics.

  title={Effects of electrostatic interactions on ligand dissociation kinetics.},
  author={Aykut Erbaş and M{\'o}nica Olvera de la Cruz and John Frederick Daniel Marko},
  journal={Physical review. E},
  volume={97 2-1},
We study unbinding of multivalent cationic ligands from oppositely charged polymeric binding sites sparsely grafted on a flat neutral substrate. Our molecular dynamics simulations are suggested by single-molecule studies of protein-DNA interactions. We consider univalent salt concentrations spanning roughly a 1000-fold range, together with various concentrations of excess ligands in solution. To reveal the ionic effects on unbinding kinetics of spontaneous and facilitated dissociation… CONTINUE READING