Effects of electroacupuncture on depression and the production of glial cell line-derived neurotrophic factor compared with fluoxetine: a randomized controlled pilot study.

@article{Sun2013EffectsOE,
  title={Effects of electroacupuncture on depression and the production of glial cell line-derived neurotrophic factor compared with fluoxetine: a randomized controlled pilot study.},
  author={Hua Sun and Hui Zhao and Chi Ma and Fei Bao and Jie Zhang and Dao-hai Wang and Yun-xiang Zhang and Wei He},
  journal={Journal of alternative and complementary medicine},
  year={2013},
  volume={19 9},
  pages={
          733-9
        }
}
  • Hua Sun, H. Zhao, +5 authors W. He
  • Published 2013
  • Medicine
  • Journal of alternative and complementary medicine
BACKGROUND AND OBJECTIVE Postmortem studies indicate that the number and density of glial cells are reduced in different brain regions of patients with depression. Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the pathogenesis of depressive disorder (DD) and might be a biomarker for damage to nerve cells. In this study, we compared the therapeutic effects of electroacupuncture (EA) and fluoxetine, a serotonin reuptake inhibitor, on DD patients, focusing on the… Expand
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Mechanisms Underlying the Antidepressant Effect of Acupuncture via the CaMK Signaling Pathway
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Electroacupuncture and fluoxetine regulated the expression of key proteins in the CaMK signaling pathway, which is related to depression, in the hippocampi of rats, indicating that acupuncture at Baihui (GV20) and Shenting (GV24) may alleviate depressive symptoms and reduce work- and life-related burdens and stress by regulating the Ca MK signaling pathway. Expand
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The findings support blood GDNF levels as a biomarker of depression as a whole, but the results were modulated by psychiatric diagnosis, age of included subjects, and sampling sources. Expand
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The Alterations of IL-1Beta, IL-6, and TGF-Beta Levels in Hippocampal CA3 Region of Chronic Restraint Stress Rats after Electroacupuncture (EA) Pretreatment
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It is indicated that administration of Seroxat alone or in combination with acupuncture/electroac acupuncture can produce a significant effect in patients with primary unipolar depression and acupuncture/Electroacupuncture has a rapid onset of therapeutic effect and produces a noticeable improvement in obsessive-compulsive, depressive and anxiety symptoms. Expand
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