Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells.

@article{Kawashima2010EffectsOE,
  title={Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells.},
  author={Akiko Kawashima and Tsuyoshi Harada and Hideaki Kami and Takashi Yano and Kazunori Imada and Kiyoshi Mizuguchi},
  journal={The Journal of nutritional biochemistry},
  year={2010},
  volume={21 4},
  pages={
          268-77
        }
}
  • Akiko Kawashima, Tsuyoshi Harada, +3 authors Kiyoshi Mizuguchi
  • Published in
    The Journal of nutritional…
    2010
  • Biology, Medicine
  • Placebo-controlled clinical studies suggest that intake of n-3 polyunsaturated fatty acids improves neurological disorders such as Alzheimer's disease, Huntington's disease and schizophrenia. To evaluate the impact of eicosapentaenoic acid (EPA), we orally administered highly purified ethyl EPA (EPA-E) to rats at a dose of 1.0 mg/g per day and measured long-term potentiation of the CA1 hippocampal region, a physiological correlate of synaptic plasticity that is thought to underlie learning and… CONTINUE READING

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