Effects of echistatin and an RGD peptide on orthodontic tooth movement.

@article{Dolce2003EffectsOE,
  title={Effects of echistatin and an RGD peptide on orthodontic tooth movement.},
  author={Calogero Dolce and A Vakani and L. Archer and Joyce A Morris-Wiman and L S Holliday},
  journal={Journal of dental research},
  year={2003},
  volume={82 9},
  pages={682-6}
}
We tested whether orthodontic tooth movement (OTM) could be blocked by local administration of echistatin or an arginine-glycine-aspartic acid (RGD) peptide, agents known to perturb bone remodeling, adjacent to maxillary molars in rats. These molecules were incorporated into ethylene-vinyl acetate (ELVAX), a non-biodegradable, sustained-release polymer. In vitro experiments showed that the echistatin and RGD peptide were released from ELVAX in active forms at levels sufficient to disrupt… CONTINUE READING
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