Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: Results of a pilot study

@article{Trautman1995EffectsOE,
  title={Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: Results of a pilot study},
  author={Paul D. Trautman and Heino F L Meyer-Bahlburg and J Postelnek and Maria I. New},
  journal={Psychoneuroendocrinology},
  year={1995},
  volume={20},
  pages={439-449}
}

Cognitive outcome of offspring from dexamethasone-treated pregnancies at risk for congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

TLDR
Findings on cognitive function in CAH girls with long-term DEX exposure contribute to concerns about potentially adverse cognitive after effects of such exposure, and replications in larger samples are required.

Long-term follow-up of prenatally treated children at risk for congenital adrenal hyperplasia: does dexamethasone cause behavioural problems?

TLDR
The clinical significance of the observed difference in sociability cannot be determined within the frameworks of this study, but additional studies of larger cohorts are essential to make more decisive conclusions on the safety of the treatment.

Cognitive and social function in girls with congenital adrenal hyperplasia — Influence of prenatally administered dexamethasone

TLDR
Prenatal treatment with Dex creates for CAH-affected females better conditions for cognitive development, and it is recommended that prenatal treatment inCAH-unaffected female fetuses should be stopped as soon as possible after the exclusion of the disease.

Prenatal Glucocorticoid Treatment and Later Mental Health in Children and Adolescents

TLDR
An association between prenatal exposure to sGC and child mental health is reported, supportive of the idea that sGC has a programming effect on the fetal brain.

Effects of prenatal dexamethasone treatment on physical growth, pituitary-adrenal hormones, and performance of motor, motivational, and cognitive tasks in juvenile and adolescent common marmoset monkeys.

TLDR
The increased palatable-reward motivation and decreased social motivation observed in early DEX subjects provide experimental support for the clinical reports that prenatal glucocorticoid treatment impairs social development and predisposes to metabolic syndrome.

Long-term outcome of prenatal dexamethasone treatment of 21-hydroxylase deficiency.

TLDR
The findings indicate that long-term follow-ups of this group of patients are of extreme importance and that future DEX treatment of CAH may be questioned, and it is important that the parents are thoroughly informed about the potential risks and uncertainties, as well as the benefits, of this treatment.

Effects of prenatal dexamethasone treatment on postnatal physical, endocrine, and social development in the common marmoset monkey.

TLDR
Novel primate in vivo evidence for postnatal effects of prenatal synthetic glucocorticoid exposure is presented, indicating the importance of improved understanding of this acute clinical treatment in terms of its long-term effects on offspring well-being.

Deciphering the link and direction between attention-deficit/hyperactivity disorder symptoms and obesity : common behavioural or prenatal pathways?

TLDR
An association between prenatal exposure to sGC and child mental health is reported, supportive of the idea that sGC has a programming effect on the fetal brain.

Use of glucocorticoids during pregnancy and risk of attention-deficit/hyperactivity disorder in offspring: a nationwide Danish cohort study

TLDR
This study provides no evidence of a causal association between prenatal exposure to GCs and risk of ADHD and compared with the general population level.
...

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