Effects of early gestational undernutrition on fetal growth, organ development, and placentomal composition in the bovine.

@article{Long2009EffectsOE,
  title={Effects of early gestational undernutrition on fetal growth, organ development, and placentomal composition in the bovine.},
  author={N. M. Long and Kimberly Ann Vonnahme and Bret W. Hess and Peter W. Nathanielsz and Stephen P. Ford},
  journal={Journal of animal science},
  year={2009},
  volume={87 6},
  pages={
          1950-9
        }
}
Fetal intrauterine growth restriction (IUGR) is known to negatively affect offspring health postnatally. This study evaluated the impacts of early gestational undernutrition followed by realimentation on bovine fetal and placental growth. Thirty multiparous beef cows bred to a single sire and gestating female fetuses were fed to meet NRC recommendations (control; n = 15) or fed below NRC recommendations (68.1% of NE(m) and 86.7% of MP recommendations; nutrient restricted, NR; n = 15) from d 30… 

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References

SHOWING 1-10 OF 51 REFERENCES

The effect of maternal undernutrition on ovine fetal growth.

Although maternal and fetal plasma IGF-I levels increased with gestation and the placentome morphology altered in all ewes (P<0.05), the fall in placental mass, amniotic and allantoic glucose concentrations, and maternal plasma glucose and insulin levels in underfed eWes in late gestation may have compromised fetal substrate delivery.

Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring.

It is demonstrated that a bout of maternal undernutrition during early to midgestation in sheep increased BW and fat deposition during adolescence and dysregulated glucose uptake in the absence of any change in birth weight.

Maternal Undernutrition from Early- to Mid-Gestation Leads to Growth Retardation, Cardiac Ventricular Hypertrophy, and Increased Liver Weight in the Fetal Sheep

Altered alterations in fetal/placental development may be beneficial to early fetal survival in the face of a nutrient restriction, but their effects later in gestation as well as in postnatal life need further investigation.

Nutrient partitioning and fetal growth in rapidly growing adolescent ewes.

The data suggest that in rapidly growing adolescent ewes, the established anabolic drive to maternal tissue synthesis is maintained at the expense of the gradually evolving nutrient requirements of the gravid uterus, resulting in a major restriction in placental growth and a highly significant decrease in birthweight.

Influence of maternal pre-pregnancy body composition and diet during early–mid pregnancy on cardiovascular function and nephron number in juvenile sheep

The data suggest that maternal body composition around conception is as important as the level of nutrient intake during early pregnancy in programming later cardiovascular health.

Maternal Nutrient Restriction Reduces Concentrations of Amino Acids and Polyamines in Ovine Maternal and Fetal Plasma and Fetal Fluids1

Novel findings demonstrate that 50% global nutrient restriction decreases concentrations of amino acids and polyamines in the ovine conceptus that could adversely impact key fetal functions and have important implications for understanding the mechanisms responsible for both intrauterine growth retardation and developmental origins of adult disease.

Placental glucose transport in growth‐restricted pregnancies induced by overnourishing adolescent sheep

It is confirmed that the small size of the placenta per se is the major limitation to placental glucose transfer in the overnourished adolescent pregnant sheep.

Maternal nutrient restriction in sheep: hypertension and decreased nephron number in offspring at 9 months of age

The present data indicate that global maternal nutrient restriction during early to mid‐gestation impairs renal nephrogenesis, increases MAP, and alters expression of AT2 and ACE without an associated change in birth weight.
...