Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer.

  title={Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer.},
  author={Z Tang and X Du and Richard F. Louie and Gerald J. Kost},
  journal={American journal of clinical pathology},
  volume={113 1},
Key MethodThirty drugs used primarily in critical care and hospital settings were tested in vitro to observe interference on glucose measurements with 6 hand-held glucose meters and a portable glucose analyzer. Paired differences of glucose measurements between drug-spiked samples and unspiked control samples were calculated to determine bias. A criterion of +/- 6 mg/dL was used as the cutoff for interference. Ascorbic acid interfered with the measurements on all glucose devices evaluated. Acetaminophen…

Continuous Glucose Monitor Interference With Commonly Prescribed Medications: A Pilot Study

Comparison of CGM glucose patterns to actual plasma glucose concentrations show several drugs, including lisinopril, albuterol, and acetaminophen, appear to interfere with commonly used CGM devices.

Evaluation of the Impact of Hematocrit and Other Interference on the Accuracy of Hospital-Based Glucose Meters

Four hospital-based glucose meter technologies were evaluated for accuracy, precision, and analytical interferences likely to be encountered in critically ill patients, with the goal of identifying and discriminating glucose meter performance specifications likely to impact intensive intravenous insulin dosing.

Validity of bedside blood glucose measurement in critically ill patients with intensive insulin therapy

The results of POC glucometer differ from laboratory glucose concentrations, especially in critically ill patients with unstable hemodynamic status while receiving several drugs, which may raise the concern about using POC devices for tight glycemic control in critical ill patients.

Evaluation of the Analytical Specificity and Clinical Application of a New Generation Hospital-based Glucose Meter in a Dialysis Setting

The results indicate that StatStrip has good clinical reliability when used in a dialysis care center and was not susceptible to hematocrit, βHB, bilirubin, lactate, or maltose interferences observed in 1 or more of the other blood glucose meters, and should minimize errors that are common to other glucometers.

Accuracy of bedside glucose measurement from three glucometers in critically ill patients*

Among intensive care unit patients, inaccurate glucose readings were most frequently falsely elevated, resulting in misinterpretation of high glucose values with subsequent inappropriate insulin administration or masking of true hypoglycemia.

GlucoMen Day Continuous Glucose Monitoring System: A Screening for Enzymatic and Electrochemical Interferents

GlucoMen Day may become the CGM system of choice for those patients who require either regular administration of drugs or their glycemia to be tightly controlled in the intensive care unit or similar environments, and clear insights are provided into the advantages offered by the use of a microdialysis-based C GM system that additionally relies on the detection of hydrogen peroxide at low operating potential.

Evaluation of the impact of hematocrit and other interference on the accuracy of hospital-based glucose meters.

Correlation to plasma hexokinase values and hematocrit interference are the main variables that differentiate glucose meters and will allow better glycemic control for critically ill patients.

[Validation of a glucose meter at an intensive care unit].

The Effects of Intravenous Vitamin C on Point-of-Care Glucose Monitoring

POC glucose monitoring should be avoided during and after vitamin C therapy, as an idiosyncratic reaction that cannot be easily corrected at the bedside using mathematical equations is suggested.



Multicenter study of oxygen-insensitive handheld glucose point-of-care testing in critical care/hospital/ambulatory patients in the United States and Canada.

The performance of GD-based, oxygen-insensitive, handheld glucose testing was technically suitable for arterial specimens in critical care patients, cord blood and heelstick specimens in neonates, and capillary and venous specimens in other patients.

In vitro drug interference with home blood-glucose-measurement systems.

Salicylic acid, acetaminophen, and ascorbic acid interfere with home blood-glucose-measurement systems, and differences were observed between the automated and homeBlood-glUCose-monitoring systems.

Laboratory evaluation of the Glucocard blood glucose test meter.

The Glucocard (Kyoto Daiichi Kagaku) blood glucose meter is designed for self-monitoring of blood glucose concentrations in capillary blood through use of an electrochemical test strip, which reduces user-related variability.

Toxic levels of acetaminophen produce a major positive interference on Glucometer Elite and Accu-chek Advantage glucose meters.

Bedside capillary glucose monitoring has become widespread in most hospitals. Glucose meters have been shown to provide a reasonably acceptable degree of accuracy compared with laboratory instruments

Use of arterial blood with bedside glucose reflectance meters in an intensive care unit: Are they accurate?

Since arterial whole blood samples give higher glucose results than arterial serum, the use of arteria whole blood in combination with reflectance meters must be recommended with caution, especially advised if the glucose values obtained with arterian whole blood are used in conjunction with a sliding scale of insulin, which depends on threshold concentrations of glucose.

Accuracy of fingerstick glucose values in shock patients.

It is suggested that fingerstick blood samples should not be used for bedside glucose analysis in patients who may have inadequate tissue perfusion.

Fingerstick glucose determination in shock.

Fingerstick glucose testing does not accurately represent venous glucose levels in severely hypotensive patients and venous reagent strip glucose testing correlates well with laboratory glucose measurements and should be the preferred method for rapid assessment of glucose level in critically ill patients with severe hypotension.

HemoCue: evaluation of a portable photometric system for determining glucose in whole blood.

The HemoCue system should prove useful for glucose measurement and was impaired only at high ambient temperature (37 degrees C); further testing outside the laboratory is warranted.

Evaluation of the quality of bedside monitoring of the blood glucose level in a teaching hospital.

  • C. TingA. Nanji
  • Medicine
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  • 1988
Continuous quality control of bedside monitoring of the blood glucose level is needed in the laboratory and at the bedside and personnel who use glucose meters should receive adequate training.