• DOI:10.1007/BF00508832
• Corpus ID: 10744121

Effects of drugs affecting the noradrenergic system on convulsions in the quaking mouse

@article{Chermat2004EffectsOD,
  title={Effects of drugs affecting the noradrenergic system on convulsions in the quaking mouse},
  author={Raymond Chermat and Liliane Doar{\'e} and François Lachapelle and Pierre Simon},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={318},
  pages={94-99}
}

• R. Chermat, L. Doaré, +1 author P. Simon
• Published 1 June 1981
• Biology
• Naunyn-Schmiedeberg's Archives of Pharmacology

SummaryHandling-induced convulsions in the quaking mouse can be blocked by: phenobarbital, pentobarbital or phenytoin; postsynaptic alpha-adrenoceptor agonists (noradrenaline, phenylephrine, CRL 40028); presynaptic alpha-adrenoceptor blockers (yohimbine, mianserine); catecholamine liberating agent (amphetamine); noradrenaline reuptake inhibitors (cocaine, imipramine, desipramine).Moreover, the protective effect of yohimbine was antagonized by clonidine, prazosin or alpha-methylparatyrosine, and the protective effect of CRL 40028 was antagonized by prazosin but not by alpha-methyltyrosine. Drugs acting by other mechanisms (pilocarpine, atropine, trihexyphenidyl, (−)-5-HTP, methysergide, pimozide, clonidine, alpha-methyl DOPA, prazosin, isoprenaline, salbutamol) did not protect against convulsions. A slight protection was obtained with high doses of apomorphine and also with (±)-propranolol. This effect is probably not related, to blockade of betaadrenoceptors because the same effect was obtained with (+)propranolol. In young quaking mice, where susceptibility to convulsions is low, both postsynaptic alpha-adrenoceptor blockers and presynaptic alpha-adrenoceptor antagonist lowered the convulsive threshold. Thus, this seems to constitute an interesting model for the in vivo study of substances which affect the central alpha-adrenoceptors either pre- or postsynaptically.