Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial.


OBJECTIVE To assess morbidity in patients with severe sepsis managed with and without drotrecogin alfa (activated). DESIGN Analysis of secondary end points in a prospective, randomized, double-blind, placebo-controlled, multicenter, phase 3 trial (PROWESS). SETTING A total of 164 medical institutions in 11 countries. PATIENTS A total of 1,690… (More)


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