Effects of down-regulation of microRNA-23a on TNF-α-induced endothelial cell apoptosis through caspase-dependent pathways.

@article{Ruan2012EffectsOD,
  title={Effects of down-regulation of microRNA-23a on TNF-α-induced endothelial cell apoptosis through caspase-dependent pathways.},
  author={W. B. Ruan and Jun-mei Xu and Suo-bei Li and Ling-Qing Yuan and Ru-ping Dai},
  journal={Cardiovascular research},
  year={2012},
  volume={93 4},
  pages={623-32}
}
AIMS Endothelial cell injury induced by inflammatory factors plays a critical role in the pathogenesis of numerous vascular diseases. MicroRNAs are well known to be implicated in cell proliferation and apoptosis in inflammatory responses; however, it remains to be determined whether microRNAs are associated with tumour necrosis factor (TNF)-α-mediated endothelial cell injury. The aim of the present study was to investigate the role of microRNAs in TNF-α-induced endothelial cell apoptosis… CONTINUE READING
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