Effects of dotarizine on 45Ca2+ movements and contractile responses in vascular smooth muscle.

@article{Tejerina1993EffectsOD,
  title={Effects of dotarizine on 45Ca2+ movements and contractile responses in vascular smooth muscle.},
  author={T. Tejerina and T. Chulia and P. Gonz{\'a}lez},
  journal={European journal of pharmacology},
  year={1993},
  volume={239 1-3},
  pages={
          75-81
        }
}
The inhibitory effects of dotarizine on 45Ca2+ movements and contractile responses were studied and compared, using the same parameters measured in rabbit aorta and basilar smooth muscle. Dotarizine 10(-9)-10(-5) M inhibited the contractile responses induced by high K+ (80 mM), noradrenaline (10(-6) M) or 5-hydroxytryptamine (5-HT, 10(-5) M). These effects were observed when dotarizine was added before or after the induced contractions and were more potent in basilar arteries than in aorta… Expand
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