Effects of dose and session duration on cocaine self-administration in rats.

@article{Wee2007EffectsOD,
  title={Effects of dose and session duration on cocaine self-administration in rats.},
  author={Sunmee Wee and Sheila E. Specio and George F. Koob},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={320 3},
  pages={1134-43}
}
Previous studies showed that an extended 6-h session duration produced an increasing rate of cocaine self-administration in rats. The present study further investigated the effect of dose and session duration on cocaine self-administration. Eight groups of rats (4 doses x 2 session durations) self-administered one of four cocaine doses (0.25, 0.5, 1, and 2 mg/kg/injection) in either 1- or 6-h sessions under a fixed-ratio schedule. In another experiment, two other groups of rats self… CONTINUE READING

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