Effects of dose and route on the disposition and kinetics of 1-butyl-1-methylpyrrolidinium chloride in male F-344 rats.

@article{Knudsen2009EffectsOD,
  title={Effects of dose and route on the disposition and kinetics of 1-butyl-1-methylpyrrolidinium chloride in male F-344 rats.},
  author={Gabriel A. Knudsen and Yaofeng Cheng and Robert K Kuester and Michelle J. Hooth and I. Glenn Sipes},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 11},
  pages={2171-7}
}
Studies were conducted to characterize the effects of dose and route of administration on the disposition of 1-butyl-1-methylpyrrolidinium (BmPy-Cl) in male Fischer-344 rats. After a single oral administration of [(14)C]BmPy-Cl (50 mg/kg), BmPy-Cl in the blood decreased rapidly after C(max) of 89.1 min with a distribution half-life (t(1/2)(alpha)) of 21 min, an elimination half-life (t(1/2)(beta)) of 5.6 h, and a total body clearance of 7.6 ml/min. After oral administration (50, 5, and 0.5 mg… CONTINUE READING

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