Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat.

@article{Baumann2009EffectsOD,
  title={Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat.},
  author={Michael Heinrich Baumann and Dorota Zolkowska and Insook Kim and Karl B. Scheidweiler and Richard B. Rothman and Marilyn A Huestis},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2009},
  volume={37 11},
  pages={2163-70}
}
Based on animal data, there is speculation that (+ or -)-3,4-methylenedioxymethamphetamine (MDMA) is neurotoxic to humans. Extrapolation of MDMA findings from animals to humans requires assessment of pharmacokinetics in various species, and low-dose administration data from rats are lacking. In this study, we examine MDMA pharmacokinetics in rats given low (2 mg/kg) and high (10 mg/kg) doses of racemic MDMA via intraperitoneal, subcutaneous, and oral routes. Repeated blood specimens were… CONTINUE READING

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