Effects of dose and interdose interval on locomotor sensitization to the dopamine agonist quinpirole.

@article{Szechtman1994EffectsOD,
  title={Effects of dose and interdose interval on locomotor sensitization to the dopamine agonist quinpirole.},
  author={Henry Szechtman and Huiliang Dai and Seham Mustafa and Haim Einat and Rose M. Sullivan},
  journal={Pharmacology, biochemistry, and behavior},
  year={1994},
  volume={48 4},
  pages={921-8}
}
To assess whether the interval between injections affects the course of locomotor sensitization to quinpirole, groups of rats were injected every 2, 4, or 8 days with quinpirole (0, 0.025, 0.25, 0.5, and 2.5 mg/kg; n = 222) and their locomotor activity monitored after each injection for a total of 10 tests. Results indicate that the number of drug injections, rather than the interval between them, predominantly controls the development of locomotor sensitization to quinpirole. It is suggested… CONTINUE READING
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