Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety.

@article{Cohen2002EffectsOD,
  title={Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety.},
  author={Pinchas Cohen and George M Bright and Alan D Rogol and A M Kappelgaard and Ron G. Rosenfeld},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 1},
  pages={90-8}
}
We evaluated the dose-response effects of GH on the growth and growth factor levels of GH-deficient patients. One hundred eleven short (-3.0 +/- 0.9 height SD score), prepubertal GH-deficient children were randomized to receive low- (L; 0.025 mg/kg per day), medium- (M; 0.05 mg/kg per day), or high- (H; 0.1 mg/kg per day) dose GH. One hundred four children completed the 2-yr study. At 2 yr, the three groups displayed increases in height SD scores of 1.4 +/- 0.1 for L, 2.2 +/- 0.1 for M, and 2.3… CONTINUE READING

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