Effects of dopamine of cerebral circulation and oxygen metabolism in endotoxic shock: an experimental study in dogs.


Experimental endotoxic shock in normocapnic dogs decreases cerebral blood flow (CBF) and increases cerebral metabolic rate of oxygen (CMRO2). In 6 animals, an iv injection of 1.0-1.5 mg/kg of Escherichia coli endotoxin was followed by iv infusion of dopamine HCI at a rate of 3-24 Micrograms/kg . min. Doses of only 5 micrograms/kg . min maximally increased… (More)


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