Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats

@article{Barrett2004EffectsOD,
  title={Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats},
  author={Andrew C. Barrett and John R. Miller and Jennifer M. Dohrmann and S. Barak Caine},
  journal={Neuropharmacology},
  year={2004},
  volume={47},
  pages={256-273}
}
Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats
TLDR
This study compared acute and chronic effects of dopamine D2- and D3-preferring ligands on choice between intravenous cocaine and palatable food in rats and showed distinct profiles, consistent with different pharmacological actions.
Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors
TLDR
Low abuse liability of BZT analogs is supported and their potential development as medications for cocaine abuse is supported by the effects of their oral pretreatment on cocaine self-administration.
Effect of GABA Agonists and GABA-A Receptor Modulators on Cocaine- and Food-Maintained Responding and Cocaine Discrimination in Rats
TLDR
Evaluated data suggest that among mechanistically diverse GABA agonists, high-efficacy GABA-A modulators may be the most effective for modifying the abuse-related effects of cocaine.
Decreased reinforcing effects of cocaine following 2 weeks of continuous d-amphetamine treatment in rats
TLDR
These data suggest that continuous d-amphetamine treatment attenuates the reinforcing effects of cocaine.
Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats
TLDR
The study of the effects of phenmetrazine on cocaine self-administration to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse, provides further support for the use of monoamine releasers as agonist medications for cocaine abuse.
Effects of Dopamine D1-Like Receptor Ligands on Food-Cocaine Choice in Socially Housed Male Cynomolgus Monkeys
  • P. Czoty, M. Nader
  • Biology, Psychology
    The Journal of Pharmacology and Experimental Therapeutics
  • 2021
TLDR
The present study in nonhuman primates found that cocaine choice was decreased only by a low-efficacy D1R agonist, and that this effect depended on the social status of the monkey, and it is demonstrated that D 1R-acting drugs affect behavior under a narrower range of conditions than D2R- acting drugs.
Prolonged Attenuation of the Reinforcing Strength of Cocaine by Chronic d-Amphetamine in Rhesus Monkeys
TLDR
The data provide further support for the use of agonist medications for cocaine abuse, and extend the conditions under which such treatment is successful to those that incorporate clinically relevant patterns of cocaine use and drug treatment.
The stereotypy-inducing effects of N-substituted benztropine analogs alone and in combination with cocaine do not account for their blockade of cocaine self-administration
TLDR
The present results suggest that the decrease in cocaine self-administration produced by the N-substituted BZT analogs is due to an antagonism of the reinforcing effects of cocaine rather than due to interference from competing behavioral overstimulation, and further supports the development of N- substituting BZt analogs as medications to treat cocaine abuse.
Self-Administration of Cocaine Induces Dopamine-Independent Self-Administration of Sigma Agonists
TLDR
The results indicate that cocaine experience induces reinforcing effects of previously inactive σ1R agonists, and that the mechanism underlying these reinforcing effects is dopamine independent, and it is further suggested that induced ρ1R mechanisms may have an essential role in treatment-resistant stimulant abuse.
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References

SHOWING 1-10 OF 85 REFERENCES
Effects of dopamine D1-like and D2-like agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions
TLDR
The results suggest that D1-like and D2-like agonists produce qualitatively different effects on cocaine self-administration that may influence their usefulness for the treatment of cocaine abuse and dependence.
Effects of selective D1 and D2 dopamine antagonists on cocaine self-administration in the rat
TLDR
The results obtained using the FR 5 and progressive-ratio schedules suggest that both D1 and D2 receptors are involved in mediating the reinforcing effects of cocaine.
Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists.
TLDR
The results suggest that D1- and D2-like receptors play fundamentally different roles in the relapse process, and either stimulation or blockade of D1 -like receptors appears to be inhibitory with respect to relapse.
Effects of dopamine D1-like and D2-like agonists in rats trained to discriminate cocaine from saline: influence of experimental history.
TLDR
Compared in rats with differing levels of experience in a cocaine discrimination procedure, the data suggest that the stimulus effects of cocaine overlap with those of D2-like agonists across a broader range of conditions than withThose of D1- like agonists.
Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys
TLDR
Chronic treatment with D1 receptor partial agonists produced dose-dependent effects on cocaine self-administration that may be relevant to their further evaluation as candidate medications for the treatment of cocaine dependence.
Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine.
TLDR
D(2) receptor-related neuronal mechanisms may be especially important in mediating the abuse-related effects of cocaine and have prominent reinforcing effects and enhance the effects of self- Administered cocaine in rats with extensive cocaine self-administration experience.
Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
  • S. B. Caine, G. Koob
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1994
TLDR
It is suggested that benzazepine dopamine D-1 antagonists, at low doses, may attenuate the reinforcing properties of cocaine more selectively than other dopamine receptor antagonists.
Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections.
TLDR
It is suggested that both D1 and D2 receptors may play a role in the discriminative stimulus effects of cocaine but that stimulation of either dopamine receptor subtype alone is not sufficient.
The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys.
  • M. Weed, W. Woolverton
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1995
TLDR
The finding that selective D1 receptor agonists can function as positive reinforcers implicates D1 receptors in the reinforcing effects of psychomotor stimulants and of other drugs that stimulate D1 antagonists.
...
1
2
3
4
5
...