Effects of dopamine D3 preferring compounds on conditioned place preference and intracranial self-stimulation in the rat

@article{KlingPetersen2005EffectsOD,
  title={Effects of dopamine D3 preferring compounds on conditioned place preference and intracranial self-stimulation in the rat},
  author={Torben Kling-Petersen and Elisabeth Ljung and L. Wollter and Kjell A. Svensson},
  journal={Journal of Neural Transmission / General Section JNT},
  year={2005},
  volume={101},
  pages={27-39}
}
Compounds showing an in vitro binding preference for the dopamine D3 receptor were tested in two models designed to assess positive reinforcement in the rat: intracranial self-stimulation (ICSS) and conditioned place preference (CPP). R-(+)-7-OH-DPAT, a D3 preferring agonist, inhibited ICSS behaviour over a wide dose range. At higher doses, a facilitation of ICSS was seen. In the CPP model, 7-OH-DPAT was inactive except at the highest dose where a significant change in preference was seen. A… 
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Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain
TLDR
The hypothesis that dopamine D3 receptors (in contrast to the D2 receptors) are mainly postsynaptically located where they display an inhibitory action on locomotor activity is supported.
Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference
TLDR
Results suggest the D3-preferring agonists could affect the reward mechanisms of the brain, however, modulation of D3 receptor function does not appear to be a significant mechanism for modifying the place conditioning effect of cocaine.
Effects of a Dopamine D3 Receptor Ligand, BP 897, on Acquisition and Expression of Food-, Morphine-, and Cocaine-induced Conditioned Place Preference, and Food-seeking Behavior in Rats
TLDR
The results indicate that BP 897 has no positive appetitive value on its own, and that a moderate degree of stimulation of D3R is not sufficient to modulate food-primed food-seeking behavior or alter incentive motivation for food, morphine, and/or their associated cues.
Neuropharmacological evidence for the role of dopamine in ventral pallidum self-stimulation
TLDR
The results suggest that DA plays a modulatory role in VP intracranial self-stimulation, and that D1, D2 and D3 receptors are involved in the mediation of this effect, although to different extents.
NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D2/3 dopamine receptor stimulation in rats
TLDR
Acquisition of place conditioning induced by systemic administration of 7-OH-DPAT is blocked by systemic NMDA receptor antagonism by MK-801 or by the AMPA/kainate receptor antagonist NBQX microinjected into the NAS shell subregion.
Respective roles of dopamine D2 and D3 receptors in food-seeking behaviour in rats
TLDR
The results indicate that reinstatement of non-reinforced responding by non-contingent food delivery and by dopamine agonists probably depend on different mechanisms.
Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats
Differential ability of D1 and D2 dopamine receptor agonists to induce and modulate expression and reinstatement of cocaine place preference in rats
TLDR
D1, but not D2/D3, agonists mediate rewarding effects and reinstatement of cocaine place preference, but the reinstating effects differ markedly from self-administration paradigms.
Maternal deprivation and handling modify the effect of the dopamine D3 receptor agonist, BP 897 on morphine-conditioned place preference in rats
TLDR
It is shown that maternal deprivation and handling induced a prolonged morphine CPP, and different changes of D2/D3 receptor functioning revealed after morphine C PP.
Effects on locomotor activity after local application of (+)-UH232 in discrete areas of the rat brain
TLDR
Both (+)-UH232 and raclopride produced a dose dependent decrease in spontaneous locomotor activity when examined as the total activity count over 60 minutes after local application into the N Acc.
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