Effects of dopamine D3 preferring compounds on conditioned place preference and intracranial self-stimulation in the rat

@article{KlingPetersen1995EffectsOD,
  title={Effects of dopamine D3 preferring compounds on conditioned place preference and intracranial self-stimulation in the rat},
  author={T. Kling-Petersen and Elisabeth Ljung and L. Wollter and K. -G. Svensson},
  journal={Journal of Neural Transmission / General Section JNT},
  year={1995},
  volume={101},
  pages={27-39}
}
Compounds showing an in vitro binding preference for the dopamine D3 receptor were tested in two models designed to assess positive reinforcement in the rat: intracranial self-stimulation (ICSS) and conditioned place preference (CPP). R-(+)-7-OH-DPAT, a D3 preferring agonist, inhibited ICSS behaviour over a wide dose range. At higher doses, a facilitation of ICSS was seen. In the CPP model, 7-OH-DPAT was inactive except at the highest dose where a significant change in preference was seen. A… CONTINUE READING
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