Effects of dopamine D(2)-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition.

@article{Collins2014EffectsOD,
  title={Effects of dopamine D(2)-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition.},
  author={Gregory T Collins and Jonathan A Jackson and Wouter Koek and Charles P. France},
  journal={European journal of pharmacology},
  year={2014},
  volume={729},
  pages={
          123-31
        }
}

Figures and Tables from this paper

Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats
TLDR
This study compared acute and chronic effects of dopamine D2- and D3-preferring ligands on choice between intravenous cocaine and palatable food in rats and showed distinct profiles, consistent with different pharmacological actions.
Opposing effects of dopamine D1- and D2-like agonists on intracranial self-stimulation in male rats.
TLDR
These studies provide more evidence for divergent effects of dopamine D1- and D2-family agonists on ICSS procedure in rats and suggest that ICSS may be a useful complement to other approaches for preclinical abuse potential assessment, in part because of the reproducibility of results.
Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking
TLDR
The aims of this dissertation were to evaluate the effects of the novel strategy of simultaneous treatments with a D3 receptor antagonist and D1 receptor partial agonist in animal models of drug addiction, including cue-induced reinstatement of cocaine seeking, cocaine conditioned place preference (CPP) and cocaine self-administration in rats.
Effects of single administration of apomorphine on memory and monoamine metabolism: A dose related study.
TLDR
Results show significantly enhanced activity in Skinner's box in a dose dependant manner, which would be helpful in elucidating memory enhancing effects of apomorphine at different doses and its implication for extending therapeutics in cognitive disorders.
Discriminative stimulus properties of the atypical antipsychotic amisulpride: comparison to its isomers and to other benzamide derivatives, antipsychotic, antidepressant, and antianxiety drugs in C57BL/6 mice
TLDR
(RS)-amisulpride generalized to some, but not all benzamide derivatives, and it failed to generalize to any other antipsychotic, antidepressant, or antianxiety drugs tested.
Discriminative stimulus effects of 3,4-methylenedioxypyrovalerone (MDPV) and structurally related synthetic cathinones
The 3,4-methylenedioxypyrovalerone (MDPV), and other structurally related synthetic cathinones, are popular alternatives to prototypical illicit psychostimulants, such as cocaine and methamphetamine.
Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity
TLDR
Computational modeling provided a structural basis for the D2R selectivity of 1, illustrating how subtle differences in the highly homologous orthosteric binding site (OBS) differentially affect D 2R/D3R affinity and functional efficacy.
2 Running title : Effects D 2 and D 3 ligands on cocaine choice in rats
TLDR
This research presents a novel and scalable approach called “SmartLabeling” that allows for real-time monitoring of the effects of drugs on the integrity of the immune system and theiradministration.
...
...

References

SHOWING 1-10 OF 41 REFERENCES
Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats
TLDR
Significant differences in the discriminative stimulus of cocaine that are due to feeding conditions and not to the use of different reinforcers across procedures are demonstrated.
Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice
TLDR
The present data suggest an involvement of DA D5R in the locomotor stimulant effects of cocaine, and the antagonism data suggest a role of the D1 receptor in the behavioraleffects of cocaine.
Effects of dopamine D1-like and D2-like agonists in rats trained to discriminate cocaine from saline: influence of experimental history.
TLDR
Compared in rats with differing levels of experience in a cocaine discrimination procedure, the data suggest that the stimulus effects of cocaine overlap with those of D2-like agonists across a broader range of conditions than withThose of D1- like agonists.
Antagonism of the discriminative stimulus effects of cocaine at two training doses by dopamine D2-like receptor antagonists
TLDR
Test for the first time an antagonist that is selective for the dopamine D2 receptor within the D2-like receptor subfamily demonstrates that antagonism by L-741,626 implies that stimulation of D2 receptors alone (not D3 or D4 receptors) is sufficient to mediate cocaine's discriminative stimulus effects.
The role of dopamine receptor subtypes in the discriminative stimulus effects of amphetamine and cocaine in rats.
TLDR
A critical role of D2 receptor subtypes in the discriminative stimuli of amphetamine and cocaine in rats is indicated, as well as a less pronounced involvement of D1 and D3 subtype ligands in the effects under study.
Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice
TLDR
The present results on the stimulation of activity and interoceptive/subjective effects of cocaine are consistent with the previously reported disregulation of dopamine synthesis in DA D4R KO mice, and further suggest a role of the DA D 4R in vulnerability to stimulant abuse.
Dopamine D3 Receptors Mediate the Discriminative Stimulus Effects of Quinpirole in Free-Feeding Rats
TLDR
Feeding conditions affecting the behavioral effects of direct-acting DA receptor agonists might also have an impact on the effects of indirect-acting agonists such as cocaine and amphetamine.
Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections.
TLDR
It is suggested that both D1 and D2 receptors may play a role in the discriminative stimulus effects of cocaine but that stimulation of either dopamine receptor subtype alone is not sufficient.
Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice
TLDR
The present data indicate an involvement of D2 DA receptors in the locomotor-stimulating effects and the interoceptive discriminative-stimulus effects of cocaine in WT subjects, suggesting redundant dopaminergic mechanisms for the discrim inative- Stimulus interoceptions of cocaine.
Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes.
The involvement of dopamine (DA) receptor subtypes in the discriminative stimulus effects of cocaine was investigated in squirrel monkeys trained to discriminate cocaine from vehicle using a
...
...