Effects of donor age, gender, and in vitro cellular aging on the phenotypic, functional, and molecular characteristics of mouse bone marrow-derived mesenchymal stem cells.

@article{Katsara2011EffectsOD,
  title={Effects of donor age, gender, and in vitro cellular aging on the phenotypic, functional, and molecular characteristics of mouse bone marrow-derived mesenchymal stem cells.},
  author={Olga Katsara and Louisa G. Mahaira and Eleni G. Iliopoulou and Ardiana Moustaki and Aristidis Antsaklis and Dimitrios Loutradis and Konstantinos Stefanidis and Constantin N. Baxevanis and Michael Papamichail and Sonia A. Perez},
  journal={Stem cells and development},
  year={2011},
  volume={20 9},
  pages={
          1549-61
        }
}
Mesenchymal stem cells (MSCs) are a very important adult stem cell population with a multitude of potential applications in regenerative medicine. The thorough characterization of the bone marrow MSC (BM-MSC) population derived from the BALB/c species was essential, considering the significance of the murine model amongst animal models. In the present study, we examined the effect of gender, age, and in vitro culture on the basic properties (proliferation, differentiation, and immunosuppressive… CONTINUE READING
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