Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia

@article{Kwon2014EffectsOD,
  title={Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia},
  author={Kyoung Ja Kwon and Min Kyeong Kim and Eun Joo Lee and Jung Nam Kim and Bo-Ryoung Choi and Soo Young Kim and Kyu Suk Cho and Jung-Soo Han and Hahn Young Kim and Chan Young Shin and Seol-Heui Han},
  journal={Journal of the Neurological Sciences},
  year={2014},
  volume={347},
  pages={66-77}
}
Vascular dementia (VaD) is the second most common form of dementia caused by cerebrovascular disease. Several recent reports demonstrated that cholinergic deficits are implicated in the pathogenesis of VaD and that cholinergic therapies have shown improvement of cognitive function in patients with VaD. However, the precise mechanisms by which donepezil achieves its effects on VaD are not fully understood. Donepezil hydrochloride is an acetylcholinesterase inhibitor (AChEI) currently used for… Expand
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References

SHOWING 1-10 OF 79 REFERENCES
Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis.
TLDR
It is found that chronic treatment of donepezil enhanced, and scopolamine suppressed phosphorylation of cAMP response element binding protein (CREB), which was involved in cell survival, in the DG. Expand
Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats
TLDR
These neuroprotective effects were prevented by coinjection with mecamylamine, a nicotinic acetylcholine-receptor (nAChR) antagonist, indicating that protection was mediated by nA cholinesterase activation. Expand
Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer’s disease
TLDR
Data of prior investigations are confirmed that a down-regulation of BDNF in serum and brain of AD patients seems to begin with the first clinical symptoms and to be persistent, and a treatment with the AChE-inhibitor donepezil is accompanied with an increase ofBDNF serum concentration in AD patients reaching the level of healthy controls. Expand
Increase of SCF plasma concentration during donepezil treatment of patients with early Alzheimer's disease.
TLDR
It is indicated that donepezil treatment of AD patients is associated with an up-regulation of SCF plasma levels, which may contribute to neuroprotection and neurogenesis in the central nervous system. Expand
Nicotinic Acetylcholine Receptor-Mediated Neuroprotection by Donepezil Against Glutamate Neurotoxicity in Rat Cortical Neurons
TLDR
The results suggest that donepezil not only protects cortical neurons against glutamate neurotoxicity via α4β2- and α7-nAChRs but also prevents apoptotic neuronal death. Expand
Concurrent administration of cilostazol with donepezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoperfusion in rats
TLDR
Concurrent treatment with cilostazol and donepezil effectively prevented the occurrence of neuropathological alterations in the white matter by activation of p-CREB and Bcl-2, thereby resulting in improvement of spatial learning memory in rats subjected to chronic cerebral hypoperfusion. Expand
Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats.
TLDR
It is suggested that donepezil can clearly minimize learning impairments induced by treatments that cause central cholinergic deficiencies in rats, and these findings support the clinical efficacy ofdonepezil in Alzheimer's disease. Expand
Expression of APP, BACE1, AChE and ChAT in an AD model in rats and the effect of donepezil hydrochloride treatment.
TLDR
Donepezil HCl was able to significantly decrease learning and memory damage in a rat model of Alzheimer's disease and the effect of donepezil hydrochloride (HCl) treatment. Expand
Mechanisms of Neuroprotective Effects of Nicotine and Acetylcholinesterase Inhibitors: Role of α4 and α7 Receptors in Neuroprotection
TLDR
Results suggest that nicotine as well as AChE inhibitors, donepezil and galantamine, prevent glutamate neurotoxicity through α4 and α7 nAChRs and the PI3K-Akt pathway. Expand
Cilostazol Protects Against Brain White Matter Damage and Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion
TLDR
It is suggested that cilostazol is potentially useful for the treatment of cognitive impairment in poststroke patients and exerts a brain-protective effect through the CREB phosphorylation pathway leading to upregulation of Bcl-2 and COX-2 expressions. Expand
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