Effects of dna-dependent protein kinase inhibition by NU7026 on dna repair and cell survival in irradiated gastric cancer cell line N87.

Abstract

UNLABELLED Repair of radiation-induced dna double-strand breaks is a key mechanism in cancer cell radio-resistance. The synthesized compound NU7026 specifically inhibits dna-dependent protein kinase (dna-pk) within the non-homologous end-joining repair mechanism. Earlier studies demonstrated increased radiosensitivity in dna-pk deficient cells compared with… (More)
DOI: 10.3747/co.21.1509

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@article{Niazi2014EffectsOD, title={Effects of dna-dependent protein kinase inhibition by NU7026 on dna repair and cell survival in irradiated gastric cancer cell line N87.}, author={M Tamim Niazi and G Mok and Mitra Heravi and Lawrence Lee and T E Vuong and Raquel S. Aloyz and Lawrence C. Panasci and Thierry Muanza}, journal={Current oncology}, year={2014}, volume={21 2}, pages={91-6} }