Effects of dizocilpine (MK-801) on motor activity and memory

  title={Effects of dizocilpine (MK-801) on motor activity and memory},
  author={Robert J. Carey and Huiliang Dai and Junmin Gui},
 The effects of MK-801 upon motor activity and memory were assessed in a novel use of open-field behavior testing. In this study, rats were treated with different doses of MK-801 (0.025, 0.05, 0.1 and 0.2 mg/kg) and given a brief 10-min exposure to an open-field in which locomotor activity and within-session habituation were measured. Doses of MK-801 ≤0.1 mg/kg had no effect upon locomotor activity or within-session habituation. MK-801 0.2 mg/kg produced a marked hyperlocomotion and completely… CONTINUE READING


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