Effects of divalent metal cations on composition and neoplasia-specific antigenicity of chromatins.

  title={Effects of divalent metal cations on composition and neoplasia-specific antigenicity of chromatins.},
  author={Sherry Dupere and Susan Holland and S Gawne and K E Cancelliere and B A Sedita and Philip J. Dale and E D Jarrell and T. E. O'CONNOR},
  journal={Cancer research},
  volume={43 10},
The antigenicity and composition of chromatins differ markedly in chromatin preparations obtained by different procedures. Rat Novikoff hepatoma chromatin (NC) obtained by the "salt precipitation" and the micrococcal nuclease digestion procedures using significant levels of EDTA and NaCl each shows a common complement fixation (CF) capacity, exceeding chromatin preparations obtained from normal rat liver when tested with rabbit antisera raised to dehistonized NC. In contrast, "structured" NC… CONTINUE READING


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