Effects of dithiocarbamates on intestinal absorption and organ distribution of cadmium chloride in mice.

@article{Andersen1989EffectsOD,
  title={Effects of dithiocarbamates on intestinal absorption and organ distribution of cadmium chloride in mice.},
  author={Ole Andersen and Jesper Bo Nielsen and M. M. Jones},
  journal={Pharmacology \& toxicology},
  year={1989},
  volume={64 3},
  pages={
          239-43
        }
}
Earlier publications have demonstrated that diethyldithiocarbamate (DDC) antagonizes the acute toxicity of injected CdCl2 but enhances the acute toxicity of orally administered CdCl2, most likely due to the high lipophilicity of DDC and the complex formed with the Cd++ ion. This study demonstrates that the hydrophilic dithiocarbamates dihydroxyethyldithiocarbamate (DHE-DTC) and N-methyl-N-glucamyl dithiocarbamate (NMG-DTC) also enhance the intestinal absorption of orally administered CdCl2 in… 
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on the acute toxicity of metals have been reviewed by Aaseth,’ B~lman,~~ Catsch and Harm~th-Hoene,~~ Jones,’I4 May and B~lman,’~~ and specifically for cadmium by Andersen6 and Nordberg.’@ In most of
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Structure and acidity of carbamic acid, and its thio, dithio and sila dervatives
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TLDR
Oral administered DDC enhanced cadmium-induced duodenal and ileal tissue damage and inhibition of peristalsis, as indicated by an increased intestinal transit time and the whole-body retention of Cadmium was increased by oral DDC administration.
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TLDR
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TLDR
It was concluded that certain dithiocarbamates effectively mobilize and promote excretion of Cd which has been absorbed from one of the natural portals of entry.
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TLDR
Three analogs of Cd-dithiocarbamate were compared for their relative efficacies in promoting organ mobilization and excretion of metallothionein-bound cadmium (Cd).
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TLDR
DEDTC (but neither of the other compounds) increased the concentration of cadmium in the brain from control levels of 49 +/- 5 ppb to 105 +/- 16 ppb and GPC analysis of bile revealed differences in the distribution of Cd in the elution fractions after the first injections of the individual dithiocarbamates.
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TLDR
It has been possible to show that the accumulation of cadmium in the brain and kidney as well as the survival rates can be correlated with a numerical measure of the polarity of the groups R1 and R2, and a composite factor for antidotal efficacy which incorporates survival rate, brain Cadmium levels and kidney cadmiam levels is constructed.
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TLDR
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