Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression.

@article{Fernndez2005EffectsOD,
  title={Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression.},
  author={Carlos Hern{\'a}ndez Fern{\'a}ndez and Miguel Mart{\'i}n and Diego G{\'o}mez-Coronado and Miguel Angel Lasunci{\'o}n},
  journal={Journal of lipid research},
  year={2005},
  volume={46 5},
  pages={920-9}
}
Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes. The aim of the present study was to elucidate the stringency of the requirement for cholesterol as a regulator of proliferation and cell cycle progression, compared with other sterols of the cholesterol biosynthesis pathway. Human promyelocytic HL-60 cells were cultured in cholesterol-free medium and… CONTINUE READING