Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.

@article{Ploplis1995EffectsOD,
  title={Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.},
  author={Victoria A. Ploplis and Peter Carmeliet and S Vazirzadeh and Ilse Van Vlaenderen and Lieve Moons and Edward F Plow and D{\'e}sir{\'e} Collen},
  journal={Circulation},
  year={1995},
  volume={92 9},
  pages={2585-93}
}
BACKGROUND Circumstantial evidence suggests that the plasminogen/plasmin system plays a role in many biological processes, including hemostasis, cell migration, and development. METHODS AND RESULTS The in vivo function of the plasminogen/plasmin system was studied by generation of plasminogen-deficient (Plg-/-) mice. Inactivation of the murine plasminogen… CONTINUE READING