Effects of disrupting the cholinergic system on short-term spatial memory in rats

@article{Andrews1994EffectsOD,
  title={Effects of disrupting the cholinergic system on short-term spatial memory in rats},
  author={John S. Andrews and J. H. M. Jansen and S. F. Linders and Anthonius Princen},
  journal={Psychopharmacology},
  year={1994},
  volume={115},
  pages={485-494}
}
The effects of disrupting the muscarinic or nicotinic systems on short-term spatial memory were investigated using a delayed matching to position (DMTP) procedure. Rats were trained on the DMTP until stability and then divided into two groups: one group was implanted with an indwelling cannula aimed at the lateral ventricle. The cannulated group received injections of selective muscarinic antagonists (pirenzepine, M1; AFDX 116, M2; UH-AH 37, M1/M3) or hemicholinium-3 (a choline uptake inhibitor… CONTINUE READING

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