Effects of disease causing mutations on the essential motions in proteins.

@article{Achary2009EffectsOD,
  title={Effects of disease causing mutations on the essential motions in proteins.},
  author={Malkaram Sridhar Achary and Hampapathalu Adimurthy Nagarajaram},
  journal={Journal of biomolecular structure & dynamics},
  year={2009},
  volume={26 5},
  pages={609-24}
}
This study embodies a detailed comparative analysis of the essential motions of the Wild type and the eight different disease mutant forms of the Human CYP1b1. The mutations considered in this study have been implicated in Primary Congenital Glaucoma, an in-born, genetic disorder associated with eye-abnormality. The principal component analysis for Wild… CONTINUE READING