Effects of direct infusion of bone marrow-derived progenitor cells and indirect mobilization of hematopoietic progenitor cells on atherosclerotic plaque and inflammatory process in atherosclerosis.

@article{Tousoulis2013EffectsOD,
  title={Effects of direct infusion of bone marrow-derived progenitor cells and indirect mobilization of hematopoietic progenitor cells on atherosclerotic plaque and inflammatory process in atherosclerosis.},
  author={Dimitris Tousoulis and Alexandros Briasoulis and Georgia Vogiatzi and Aggeliki Valatsou and Polina Kourkouti and Alkistis Pantopoulou and Nikolaos Papageorgiou and Despina Perrea and Christodoulos Stefanadis},
  journal={International journal of cardiology},
  year={2013},
  volume={168 5},
  pages={4769-74}
}
BACKGROUND We sought to investigate the effects of lin-/sca+ cells, endothelial progenitor cells (EPCs) and granulocyte colony-stimulating factor (G-CSF) administration on atherosclerotic plaque progression. METHODS Apolipoprotein E-deficient (apoE(-/-)) mice were splenectomized and treated with high-cholesterol diet for 6 weeks in order to induce atherosclerotic plaque development. Bone marrow-derived Lin-/sca-1+ cells were isolated and further cultured to early growth endothelial progenitor… CONTINUE READING
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